Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation
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چکیده
منابع مشابه
Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization
Background Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the reso...
متن کامل29 Allergic Rhinitis to Ragweed Pollen
BALF. IL-4 and IL-5 decreased significantly (P # 0.05) after AEBSF treatment while a significant (P # 0.05) increase was observed in IL-10 in BALF. Airway inflammation reduced significantly as revealed by lung histopathology, EPO activity and cysteinyl leukotrienes in BALF after treatment. AEBSF also suppressed oxidative stress in terms of 8-isoprostane in BALF. Among the treatment doses, 10 an...
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BACKGROUND Macrophages are highly heterogeneous and plastic cells that are involved in all stages of atherogenesis. They can undergo polarization by shifting between M1 and M2 functional phenotypes. However, the role of macrophage polarization and the molecular mechanism in modulating atherosclerotic plaque stability remain incompletely understood. Our study investigated the role of STAT6 in re...
متن کاملRagweed pollen: morphological changes on incubation with saliva from ragweed-allergic and non-allergic humans.
1. The interactions between ragweed pollen and the saliva from ragweed-sensitive and non-sensitive humans have been examined. A number of morphological changes of the pollen grains take place under the conditions of the incubation. Of these changes, two occur only with incubation in allergic saliva and one occurs with the use of ‘inflammatory’ saliva, allergic or non-allergic. 2. The two change...
متن کاملInhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization
Macrophages play a key role in the pathogenesis of liver granuloma and fibrosis in schistosomiasis. However, the underlying mechanisms have not been fully characterized. This study revealed that the macrophages infiltrating the liver tissues in a murine model of Schistosoma japonica infection exhibited M2 functional polarization, and Notch1/Jagged1 signaling was significantly upregulated in the...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2019
ISSN: 1933-0219,1935-3456
DOI: 10.1038/s41385-019-0187-8